Fever

70.0 kgHome

Antipyretics

DrugDoseInterval
Acetaminophen PO1050 mg (15 mg/kg, max 1 g)q4-6h
Acetaminophen PR1400 mg (20 mg/kg)q6h
Ibuprofen (>6 mo)700 mg (10 mg/kg, max 600)q6h

Fever workup by age

<28 d: full sepsis w/u, empiric Amp + Gent + Acyclovir. 29-60 d: Step-by-step / PECARN, +/- LP. >60 d well-appearing: source-directed.

Empiric antibiotics

  • Ceftriaxone

    Sepsis, meningitis

    IV/IM
    Dose
    2000 mgMax
    Volume
    20.0 mL
    IV/IM• 100 mg/mL (reconstituted)• 100 mg/kg

    Meningitis dose 100 mg/kg; non-CNS 50 mg/kg

  • Ampicillin

    Neonatal sepsis, GBS

    IV
    Dose
    2000 mgMax
    Volume
    20.0 mL
    IV• 100 mg/mL• 50 mg/kg

  • Gentamicin

    Gram-negative coverage

    IV
    Dose
    120 mgMax
    Volume
    3.00 mL
    IV• 40 mg/mL• 2.5 mg/kg

  • Acyclovir

    Neonatal/pediatric HSV

    IV
    Dose
    1000 mgMax
    Volume
    20.0 mL
    IV over 1 hr• 50 mg/mL• 20 mg/kg