Seizure / Status Epilepticus

First-line (benzos)

• Lorazepam

  Status epilepticus

  IV/IO/IM
  Dose

  4.00 mgMax

  Volume

  2.00 mL
  ⚠Capped at max dose — Max single dose: 4.00 mg
  IV/IO/IM• 2 mg/mL• 0.1 mg/kg

• Midazolam (Seizure)

  Status epilepticus

  IM/IN/Buccal
  Dose

  10.0 mgMax

  Volume

  2.00 mL
  ⚠Capped at max dose — Max single dose: 10.0 mg
  IM/IN/Buccal• 5 mg/mL• 0.2 mg/kg

• Diazepam (IV)

  Status epilepticus

  IV
  Dose

  10.0 mgMax

  Volume

  2.00 mL
  ⚠Capped at max dose — Max single dose: 10.0 mg
  IV slow push• 5 mg/mL• 0.2 mg/kg

• Diazepam (PR)

  Status epilepticus, no IV

  Per
  Dose

  20.0 mgMax

  Volume

  4.00 mL
  ⚠Capped at max dose — Max single dose: 20.0 mg
  Per rectum• 5 mg/mL gel• 0.5 mg/kg

Second-line

• Levetiracetam

  2nd line status

  IV
  Dose

  4200 mg

  Volume

  42.0 mL
  IV over 15 min• 100 mg/mL• 60 mg/kg

• Fosphenytoin

  2nd line status

  IV/IM,
  Dose

  1400 mg PE

  Volume

  28.0 mL
  IV/IM, max rate 150 mg/min• 50 mg PE/mL• 20 mg PE/kg

Status timeline