Thigh Pain

Cannot miss / life threats
Cannot miss / life threats
Diagnostic flow โ€” check first
Diagnostic flow โ€” check first
  • Unilateral thigh swelling โ†’ Doppler.
  • Pain out of proportion โ†’ compartment / nec fasc / arterial.
  • High-energy mechanism โ†’ assess for femur shaft + blood loss.
  • Burning anterolateral numbness โ†’ meralgia paresthetica.
Differential diagnosis โ€” checklist
0/15

Check off each diagnosis as you consider it. Tap the name for unique exam, lab/imaging clues, first-line confirmatory test, and management.

Traumatic0/4
Vascular0/4
Soft-tissue / nerve0/5
Inflammatory / metabolic0/2
Initial ED workup
Bedside0/5
  • Vitals
  • Inspect for swelling, asymmetry, ecchymosis, color
  • Palpate compartments, calf for cord
  • NV exam, distal pulses
  • Measure calf/thigh circumference
Labs0/3
  • CBC, CRP, CK, lactate
  • D-dimer if DVT/PE on table
  • Type & screen if femur fracture
Imaging0/4
  • XR for fracture
  • Doppler US for DVT
  • CTA for arterial occlusion
  • MRI (with & without contrast) for soft-tissue/abscess/myositis
Initial management0/5
  • Splint, elevate, analgesia
  • Anticoagulate DVT
  • Emergent fasciotomy for compartment
  • Traction splint + blood products for femur fracture
  • Surgery + abx for nec fasc / pyomyositis
Pearls / pitfalls
Pearls
  • A femoral shaft fracture can lose >1 L blood โ€” check H&H and have blood ready.
  • Statin myalgia can progress to rhabdo โ€” always check CK with dark urine.
  • Phlegmasia is limb-threatening; treat aggressively with thrombolysis, not just heparin.